dihexa nephrotoxicity Mechanisms of Cisplatin Protective effects of madecassoside against

Walking Recovery Index (WRI) As described previously [13], to objectively measure gait recovery, recordings were carried out using a fixed digital camera placed under the animals (Olympus mju 300 digital, Olympus Optical Co., Ltd., Hachioji, Tokyo, Japan), located 25 cm below and 12 cm to the side of a 100 cm long closed transparent plexiglass tunnel, and measurements and the gait recovery index were calculated, expressed as a coefficient of the length of the footprints with which the animal rests on the ground in certain phases of walking, according to the following Equation (1): where NPL stands for the non-injured animal footprint length, while EPL stands for the experimental animal footprint length, expressed in millimeters

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V. Kh. Khavinson, N. S. Linkova, and S. I. Tarnovskaya, Short Peptides Regulate Gene Expression, Springer Science and Business Media LLC, Dec. 2016. doi: 10.1007/s10517-016-3596-7

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When all participants were analyzed regardless of treatment adherence, weight reduction trends were consistent with those from the primary analysis, confirming robustness of the findings